Table of Contents 1 Report Overview 1.1 Study Scope 1.2 Major Manufacturers Covered in This Report 1.3 Market Segment by Type 1.3.1 Global Calming and Sleeping Market Size Growth Rate by Type (2019-2025) 1.3.2 Medications 1.3.3 Prescriptions 1.3.4 Over-The-Counter (OTC) 1.3.5 Sleep Laboratories 1.3.6 Sleep Apnea Devices 1.3.7 Mattresses and Pillows 1.4 Market Segment by Application 1.4.1 Global Calming and Sleeping Market Share by Application (2019-2025) 1.4.2 Insomnia 1.4.3 Sleep apnea 1.4.4 Restless Leg Syndrome (RLS) 1.4.5 Bruxism 1.4.6 Narcolepsy 1.4.7 Sleepwalking 1.5 Study Objectives 1.6 Years Considered 2 Global Growth Trends 2.1 Global Calming and Sleeping Market Size 2.1.1 Global Calming and Sleeping Revenue 2014-2025 2.1.2 Global Calming and Sleeping Sales 2014-2025 2.2 Calming and Sleeping Growth Rate by Regions 2.2.1 Global Calming and Sleeping Sales by Regions 2014-2019 2.2.2 Global Calming and Sleeping Revenue by Regions 2014-2019 2.3 Industry Trends 2.3.1 Market Top Trends 2.3.2 Market Drivers 3 Market Share by Manufacturers 3.1 Calming and Sleeping Sales by Manufacturers 3.1.1 Calming and Sleeping Sales by Manufacturers 2014-2019 3.1.2 Calming and Sleeping Sales Market Share by Manufacturers 2014-2019 3.2 Revenue by Manufacturers 3.2.1 Calming and Sleeping Revenue by Manufacturers (2014-2019) 3.2.2 Calming and Sleeping Revenue Share by Manufacturers (2014-2019) 3.2.3 Global Calming and Sleeping Market Concentration Ratio (CR5 and HHI) 3.3 Calming and Sleeping Price by Manufacturers 3.4 Key Manufacturers Calming and Sleeping Plants/Factories Distribution and Area Served 3.5 Date of Key Manufacturers Enter into Calming and Sleeping Market 3.6 Key Manufacturers Calming and Sleeping Product Offered 3.7 Mergers & Acquisitions, Expansion Plans 4 Market Size by Type 4.1 Sales and Revenue for Each Type 4.1.1 Medications Sales and Revenue (2014-2019) 4.1.2 Prescriptions Sales and Revenue (2014-2019) 4.1.3 Over-The-Counter (OTC) Sales and Revenue (2014-2019) 4.1.4 Sleep Laboratories Sales and Revenue (2014-2019) 4.1.5 Sleep Apnea Devices Sales and Revenue (2014-2019) 4.1.6 Mattresses and Pillows Sales and Revenue (2014-2019) 4.2 Global Calming and Sleeping Sales Market Share by Type 4.3 Global Calming and Sleeping Revenue Market Share by Type 4.4 Calming and Sleeping Price by Type 5 Market Size by Application 5.1 Overview 5.2 Global Calming and Sleeping Sales by Application 6 United States 6.1 United States Calming and Sleeping Breakdown Data by Company 6.2 United States Calming and Sleeping Breakdown Data by Type 6.3 United States Calming and Sleeping Breakdown Data by Application 7 European Union 7.1 European Union Calming and Sleeping Breakdown Data by Company 7.2 European Union Calming and Sleeping Breakdown Data by Type 7.3 European Union Calming and Sleeping Breakdown Data by Application 8 China 8.1 China Calming and Sleeping Breakdown Data by Company 8.2 China Calming and Sleeping Breakdown Data by Type 8.3 China Calming and Sleeping Breakdown Data by Application 9 Rest of World 9.1 Rest of World Calming and Sleeping Breakdown Data by Company 9.2 Rest of World Calming and Sleeping Breakdown Data by Type 9.3 Rest of World Calming and Sleeping Breakdown Data by Application 9.4 Rest of World Calming and Sleeping Breakdown Data by Countries 9.4.1 Rest of World Calming and Sleeping Sales by Countries 9.4.2 Rest of World Calming and Sleeping Revenue by Countries 9.4.3 Japan 9.4.4 Korea 9.4.5 India 9.4.6 Southeast Asia 10 Company Profiles 10.1 Eli Lilly 10.1.1 Eli Lilly Company Details 10.1.2 Company Description and Business Overview 10.1.3 Sales, Revenue and Market Share of Calming and Sleeping 10.1.4 Calming and Sleeping Product Introduction 10.1.5 Eli Lilly Recent Development 10.2 AstraZeneca 10.2.1 AstraZeneca Company Details 10.2.2 Company Description and Business Overview 10.2.3 Sales, Revenue and Market Share of Calming and Sleeping 10.2.4 Calming and Sleeping Product Introduction 10.2.5 AstraZeneca Recent Development 10.3 Johnson & Johnson 10.3.1 Johnson & Johnson Company Details 10.3.2 Company Description and Business Overview 10.3.3 Sales, Revenue and Market Share of Calming and Sleeping 10.3.4 Calming and Sleeping Product Introduction 10.3.5 Johnson & Johnson Recent Development 10.4 Sunovion Pharmaceuticals 10.4.1 Sunovion Pharmaceuticals Company Details 10.4.2 Company Description and Business Overview 10.4.3 Sales, Revenue and Market Share of Calming and Sleeping 10.4.4 Calming and Sleeping Product Introduction 10.4.5 Sunovion Pharmaceuticals Recent Development 10.5 Roscoe Medical 10.5.1 Roscoe Medical Company Details 10.5.2 Company Description and Business Overview 10.5.3 Sales, Revenue and Market Share of Calming and Sleeping 10.5.4 Calming and Sleeping Product Introduction 10.5.5 Roscoe Medical Recent Development 10.6 Acura Pharmaceuticals 10.6.1 Acura Pharmaceuticals Company Details 10.6.2 Company Description and Business Overview 10.6.3 Sales, Revenue and Market Share of Calming and Sleeping 10.6.4 Calming and Sleeping Product Introduction 10.6.5 Acura Pharmaceuticals Recent Development 10.7 Teva Pharmaceutical 10.7.1 Teva Pharmaceutical Company Details 10.7.2 Company Description and Business Overview 10.7.3 Sales, Revenue and Market Share of Calming and Sleeping 10.7.4 Calming and Sleeping Product Introduction 10.7.5 Teva Pharmaceutical Recent Development 10.8 Cara Therapeutics 10.8.1 Cara Therapeutics Company Details 10.8.2 Company Description and Business Overview 10.8.3 Sales, Revenue and Market Share of Calming and Sleeping 10.8.4 Calming and Sleeping Product Introduction 10.8.5 Cara Therapeutics Recent Development 10.9 Collegium Pharmaceutical 10.9.1 Collegium Pharmaceutical Company Details 10.9.2 Company Description and Business Overview 10.9.3 Sales, Revenue and Market Share of Calming and Sleeping 10.9.4 Calming and Sleeping Product Introduction 10.9.5 Collegium Pharmaceutical Recent Development 10.10 Durect Corporation 10.10.1 Durect Corporation Company Details 10.10.2 Company Description and Business Overview 10.10.3 Sales, Revenue and Market Share of Calming and Sleeping 10.10.4 Calming and Sleeping Product Introduction 10.10.5 Durect Corporation Recent Development 11 Value Chain and Sales Channels Analysis 11.1 Value Chain Analysis 11.2 Sales Channels Analysis 11.2.1 Calming and Sleeping Sales Channels 11.2.2 Calming and Sleeping Distributors 11.3 Calming and Sleeping Customers 12 Market Forecast 12.1 Global Calming and Sleeping Sales and Revenue Forecast 2019-2025 12.2 Global Calming and Sleeping Sales Forecast by Type 12.3 Global Calming and Sleeping Sales Forecast by Application 12.4 Calming and Sleeping Forecast by Regions 12.4.1 Global Calming and Sleeping Sales Forecast by Regions 2019-2025 12.4.2 Global Calming and Sleeping Revenue Forecast by Regions 2019-2025 12.5 United States Market Forecast 12.6 European Union Market Forecast 12.7 China Market Forecast 12.8 Rest of World 12.8.1 Japan 12.8.2 Korea 12.8.3 India 13 Research Findings and Conclusion 14 Appendix 14.1 Research Methodology 14.1.1 Methodology/Research Approach 14.1.1.1 Research Programs/Design 14.1.1.2 Market Size Estimation 14.1.1.3 Market Breakdown and Data Triangulation 14.1.2 Data Source 14.1.2.1 Secondary Sources 14.1.2.2 Primary Sources 14.2 Author Details 14.3 Disclaimer

List of Tables and Figures Figure Calming and Sleeping Product Picture Table Calming and Sleeping Key Market Segments Table Major Manufacturers Calming and Sleeping Covered in This Report Table Global Calming and Sleeping Market Size Growth Rate by Type 2019-2025 (M L) & (Million US$) Figure Global Calming and Sleeping Sales Market Shar by Type 2014-2025 Figure Medications Figures Table Major Manufacturers of Medications Figure Prescriptions Figures Table Major Manufacturers of Prescriptions Figure Over-The-Counter (OTC) Figures Table Major Manufacturers of Over-The-Counter (OTC) Figure Sleep Laboratories Figures Table Major Manufacturers of Sleep Laboratories Figure Sleep Apnea Devices Figures Table Major Manufacturers of Sleep Apnea Devices Figure Mattresses and Pillows Figures Table Major Manufacturers of Mattresses and Pillows Table Global Calming and Sleeping Market Share by Application 2019-2025 (M L) Figure Insomnia Use Case Figure Sleep apnea Use Case Figure Restless Leg Syndrome (RLS) Use Case Figure Bruxism Use Case Figure Narcolepsy Use Case Figure Sleepwalking Use Case Figure Calming and Sleeping Report Years Considered Figure Global Calming and Sleeping Market Size 2014-2025 (Million US$) Figure Global Calming and Sleeping Sales 2014-2019 (M L) Table Global Calming and Sleeping Market Size by Regions 2014-2019 (M L) & (Million US$) Table Global Calming and Sleeping Sales by Regions 2014-2019 (M L) Table Global Calming and Sleeping Sales Market Share by Regions 2014-2019 Figure Global Calming and Sleeping Sales Market Share by Regions 2014-2019 Figure Global Calming and Sleeping Sales Market Share by Regions in 2019 Table Global Calming and Sleeping Revenue by Regions 2014-2019 (Million US$) Table Global Calming and Sleeping Revenue Market Share by Regions 2014-2019 Figure Global Calming and Sleeping Revenue Market Share by Regions 2014-2019 Figure Global Calming and Sleeping Revenue Market Share by Regions in 2019 Table Market Top Trends Table Global Calming and Sleeping Sales by Manufacturers (2014-2019) (M L) Table Global Calming and Sleeping Sales Share by Manufacturers (2014-2019) Figure Global Calming and Sleeping Sales Share by Manufacturers in 2019 Table Calming and Sleeping Revenue by Manufacturers (2014-2019) (Million USD) Table Calming and Sleeping Revenue Share by Manufacturers (2014-2019) Figure Calming and Sleeping Value Share by Manufacturers in 2019 Table Global Calming and Sleeping Manufacturers Market Concentration Ratio (CR5 and HHI) Table Key Manufacturers Calming and Sleeping Price (2014-2019) (USD/L) Table Key Manufacturers Calming and Sleeping Plants/Factories Distribution Table Key Manufacturers Calming and Sleeping Area Served Table Date of Key Manufacturers Enter into Calming and Sleeping Market Table Key Manufacturers Calming and Sleeping Product Type Table Mergers & Acquisitions, Expansion Plans Table Global Medications Sales and Revenue (2014-2019) (M L) & (Million US$) Table Global Prescriptions Sales and Revenue (2014-2019) (M L) & (Million US$) Table Global Over-The-Counter (OTC) Sales and Revenue (2014-2019) (M L) & (Million US$) Table Global Sleep Laboratories Sales and Revenue (2014-2019) (M L) & (Million US$) Table Global Sleep Apnea Devices Sales and Revenue (2014-2019) (M L) & (Million US$) Table Global Mattresses and Pillows Sales and Revenue (2014-2019) (M L) & (Million US$) Table Global Calming and Sleeping Sales by Type (2014-2019) (M L) Table Global Calming and Sleeping Sales Share by Type (2014-2019) Figure Global Calming and Sleeping Sales Market Share by Type (2014-2019) Figure Global Calming and Sleeping Sales Market Share by Type in 2018 Table Global Calming and Sleeping Revenue by Type (2014-2019) (Million US$) Table Global Calming and Sleeping Revenue Share by Type (2014-2019) Figure Global Calming and Sleeping Revenue Market Share by Type (2014-2019) Figure Global Calming and Sleeping Revenue Market Share by Type in 2018 Table Calming and Sleeping Price by Type 2014-2019 (USD/L) Table Global Calming and Sleeping Sales by Application (2014-2019) (M L) Table Global Calming and Sleeping Sales Share by Application (2014-2019) Figure Global Sales Calming and Sleeping Market Share by Application (2014-2019) Figure Global Sales Calming and Sleeping Market Share by Application (2014-2019) Figure United States Calming and Sleeping Sales Growth Rate 2014-2019 (M L) Figure United States Calming and Sleeping Revenue Growth Rate 2014-2019 (Million US$) Table United States Calming and Sleeping Sales by Company (2014-2019) (M L) Table United States Calming and Sleeping Sales Market Share by Company (2014-2019) Figure United States Calming and Sleeping Sales Market Share by Company in 2019 Table United States Calming and Sleeping Sales by Type (2014-2019) (M L) Table United States Calming and Sleeping Sales Market Share by Type (2014-2019) Figure United States Calming and Sleeping Market Share by Type in 2019 Table United States Calming and Sleeping Sales by Application (2014-2019) (M L) Table United States Calming and Sleeping Sales Market Share by Application (2014-2019) Figure United States Calming and Sleeping Market Share by Application in 2019 Figure European Union Calming and Sleeping Sales Growth Rate 2014-2019 (M L) Figure European Union Calming and Sleeping Revenue Growth Rate 2014-2019 (Million US$) Table European Union Calming and Sleeping Sales by Company (2014-2019) (M L) Table European Union Calming and Sleeping Sales Market Share by Company (2014-2019) Figure European Union Calming and Sleeping Sales Market Share by Company in 2019 Table European Union Calming and Sleeping Sales by Type (2014-2019) (M L) Table European Union Calming and Sleeping Sales Market Share by Type (2014-2019) Figure 2018 European Union Calming and Sleeping Market Share by Type Table European Union Calming and Sleeping Sales by Application (2014-2019) (M L) Table European Union Calming and Sleeping Sales Market Share by Application (2014-2019) Figure 2018 European Union Calming and Sleeping Market Share by Application Figure China Calming and Sleeping Sales Growth Rate 2014-2019 (M L) Figure China Calming and Sleeping Revenue Growth Rate 2014-2019 (Million US$) Table China Calming and Sleeping Sales by Company (2014-2019) (M L) Table China Calming and Sleeping Sales Market Share by Company (2014-2019) Figure China Calming and Sleeping Sales Market Share by Company in 2019 Table China Calming and Sleeping Sales by Type (2014-2019) (M L) Table China Calming and Sleeping Sales Market Share by Type (2014-2019) Figure China Calming and Sleeping Market Share by Type in 2019 Table China Calming and Sleeping Sales by Application (2014-2019) (M L) Table China Calming and Sleeping Sales Market Share by Application (2014-2019) Figure China Calming and Sleeping Market Share by Application in 2019 Figure Rest of World Calming and Sleeping Sales Growth Rate 2014-2019 (M L) Figure Rest of World Calming and Sleeping Revenue Growth Rate 2014-2019 (Million US$) Table Rest of World Calming and Sleeping Sales by Company (2014-2019) (M L) Table Rest of World Calming and Sleeping Sales Market Share by Company (2014-2019) Figure Rest of World Calming and Sleeping Sales Market Share by Company in 2019 Table Rest of World Calming and Sleeping Sales by Type (2014-2019) (M L) Table Rest of World Calming and Sleeping Sales Market Share by Type (2014-2019) Figure Rest of World Calming and Sleeping Market Share by Type in 2019 Table Rest of World Calming and Sleeping Sales by Application (2014-2019) (M L) Table Rest of World Calming and Sleeping Sales Market Share by Application (2014-2019) Figure Rest of World Calming and Sleeping Market Share by Application in 2019 Table Rest of World Calming and Sleeping Sales by Countries (2014-2019) (M L) Table Rest of World Calming and Sleeping Sales Market Share by Countries (2014-2019) Figure Rest of World Calming and Sleeping Sales Market Share by Countries in 2019 Table Rest of World Calming and Sleeping Revenue by Countries (2014-2019) (Million US$) Table Rest of World Calming and Sleeping Revenue Market Share by Countries (2014-2019) Figure Rest of World Calming and Sleeping Revenue Market Share by Countries in 2019 Figure Japan Calming and Sleeping Sales Growth Rate (2014-2019) (M L) Figure Japan Calming and Sleeping Revenue Growth Rate (2014-2019) (M L) Figure Korea Calming and Sleeping Sales Growth Rate (2014-2019) (M L) Figure Korea Calming and Sleeping Revenue Growth Rate (2014-2019) (M L) Figure India Calming and Sleeping Sales Growth Rate (2014-2019) (M L) Figure India Calming and Sleeping Revenue Growth Rate (2014-2019) (M L) Figure Southeast Asia Calming and Sleeping Sales Growth Rate (2014-2019) (M L) Figure Southeast Asia Calming and Sleeping Revenue Growth Rate (2014-2019) (M L) Table Eli Lilly Company Details Table Eli Lilly Description and Business Overview Table Eli Lilly Calming and Sleeping Sales (M L), Revenue (Million US$), Price (USD/L) and Gross Margin (2014-2019) Table Eli Lilly Calming and Sleeping Sales Growth Rate (2014-2019) Table Eli Lilly Calming and Sleeping Sales Market Share in Global Market Table Eli Lilly Recent Development Table AstraZeneca Company Details Table AstraZeneca Description and Business Overview Table AstraZeneca Calming and Sleeping Sales (M L), Revenue (Million US$), Price (USD/L) and Gross Margin (2014-2019) Table AstraZeneca Calming and Sleeping Sales Growth Rate (2014-2019) Table AstraZeneca Calming and Sleeping Sales Market Share in Global Market Table AstraZeneca Recent Development Table Johnson & Johnson Company Details Table Johnson & Johnson Description and Business Overview Table Johnson & Johnson Calming and Sleeping Sales (M L), Revenue (Million US$), Price (USD/L) and Gross Margin (2014-2019) Table Johnson & Johnson Calming and Sleeping Sales Growth Rate (2014-2019) Table Johnson & Johnson Calming and Sleeping Sales Market Share in Global Market Table Johnson & Johnson Recent Development Table Sunovion Pharmaceuticals Company Details Table Sunovion Pharmaceuticals Description and Business Overview Table Sunovion Pharmaceuticals Calming and Sleeping Sales (M L), Revenue (Million US$), Price (USD/L) and Gross Margin (2014-2019) Table Sunovion Pharmaceuticals Calming and Sleeping Sales Growth Rate (2014-2019) Table Sunovion Pharmaceuticals Calming and Sleeping Sales Market Share in Global Market Table Sunovion Pharmaceuticals Recent Development Table Roscoe Medical Company Details Table Roscoe Medical Description and Business Overview Table Roscoe Medical Calming and Sleeping Sales (M L), Revenue (Million US$), Price (USD/L) and Gross Margin (2014-2019) Table Roscoe Medical Calming and Sleeping Sales Growth Rate (2014-2019) Table Roscoe Medical Calming and Sleeping Sales Market Share in Global Market Table Roscoe Medical Recent Development Table Acura Pharmaceuticals Company Details Table Acura Pharmaceuticals Description and Business Overview Table Acura Pharmaceuticals Calming and Sleeping Sales (M L), Revenue (Million US$), Price (USD/L) and Gross Margin (2014-2019) Table Acura Pharmaceuticals Calming and Sleeping Sales Growth Rate (2014-2019) Table Acura Pharmaceuticals Calming and Sleeping Sales Market Share in Global Market Table Acura Pharmaceuticals Recent Development Table Teva Pharmaceutical Company Details Table Teva Pharmaceutical Description and Business Overview Table Teva Pharmaceutical Calming and Sleeping Sales (M L), Revenue (Million US$), Price (USD/L) and Gross Margin (2014-2019) Table Teva Pharmaceutical Calming and Sleeping Sales Growth Rate (2014-2019) Table Teva Pharmaceutical Calming and Sleeping Sales Market Share in Global Market Table Teva Pharmaceutical Recent Development Table Cara Therapeutics Company Details Table Cara Therapeutics Description and Business Overview Table Cara Therapeutics Calming and Sleeping Sales (M L), Revenue (Million US$), Price (USD/L) and Gross Margin (2014-2019) Table Cara Therapeutics Calming and Sleeping Sales Growth Rate (2014-2019) Table Cara Therapeutics Calming and Sleeping Sales Market Share in Global Market Table Cara Therapeutics Recent Development Table Collegium Pharmaceutical Company Details Table Collegium Pharmaceutical Description and Business Overview Table Collegium Pharmaceutical Calming and Sleeping Sales (M L), Revenue (Million US$), Price (USD/L) and Gross Margin (2014-2019) Table Collegium Pharmaceutical Calming and Sleeping Sales Growth Rate (2014-2019) Table Collegium Pharmaceutical Calming and Sleeping Sales Market Share in Global Market Table Collegium Pharmaceutical Recent Development Table Durect Corporation Company Details Table Durect Corporation Description and Business Overview Table Durect Corporation Calming and Sleeping Sales (M L), Revenue (Million US$), Price (USD/L) and Gross Margin (2014-2019) Table Durect Corporation Calming and Sleeping Sales Growth Rate (2014-2019) Table Durect Corporation Calming and Sleeping Sales Market Share in Global Market Table Durect Corporation Recent Development Figure Calming and Sleeping Value Chain Table Calming and Sleeping Distributors List Table Calming and Sleeping Customers List Table Global Calming and Sleeping Sales Forecast 2019-2025 (M L) & (Million US$) Figure Global Calming and Sleeping Sales Forecast 2019-2025 (M L) Figure Global Calming and Sleeping Revenue Forecast 2019-2025 (Million US$) Table Global Calming and Sleeping Sales Forecast by Type 2019-2025 (M L) Figure Global Calming and Sleeping Sales Forecast by Type 2019-2025 (M L) Figure Global Calming and Sleeping Sales Market Share Forecast by Type 2019-2025 Table Global Calming and Sleeping Sales Forecast by Application 2019-2025 (M L) Figure Global Calming and Sleeping Sales Forecast by Application 2019-2025 (M L) Figure Global Calming and Sleeping Sales Market Share Forecast by Application 2019-2025 Table Global Calming and Sleeping Sales Forecast by Regions 2019-2025 (M L) Figure Global Calming and Sleeping Sales Forecast by Regions 2019-2025 (M L) Figure Global Calming and Sleeping Sales Market Share Forecast by Regions 2019-2025 Table Global Calming and Sleeping Revenue Forecast by Regions 2019-2025 (M L) Figure Global Calming and Sleeping Revenue Forecast by Regions 2019-2025 (M L) Figure Global Calming and Sleeping Revenue Market Share Forecast by Regions 2019-2025 Figure United States Calming and Sleeping Sales Forecast 2019-2025 (M L) Figure United States Calming and Sleeping Revenue Forecast 2019-2025 (Million US$) Figure European Union Calming and Sleeping Sales Forecast 2019-2025 (M L) Figure European Union Calming and Sleeping Revenue Forecast 2019-2025 (Million US$) Figure China Calming and Sleeping Sales Forecast 2019-2025 (M L) Figure China Calming and Sleeping Revenue Forecast 2019-2025 (Million US$) Figure Japan Calming and Sleeping Sales Forecast 2019-2025 (M L) Figure Japan Calming and Sleeping Revenue Forecast 2019-2025 (Million US$) Figure Korea Calming and Sleeping Sales Forecast 2019-2025 (M L) Figure Korea Calming and Sleeping Revenue Forecast 2019-2025 (Million US$) Figure India Calming and Sleeping Sales Forecast 2019-2025 (M L) Figure India Calming and Sleeping Revenue Forecast 2019-2025 (Million US$) Figure Southeast Asia Calming and Sleeping Sales Forecast 2019-2025 (M L) Figure Southeast Asia Calming and Sleeping Revenue Forecast 2019-2025 (Million US$) Table Research Programs/Design for This Report Figure Bottom-up and Top-down Approaches for This Report Figure Data Triangulation Table Key Data Information from Secondary Sources Table Key Data Information from Primary Sources

Eli Lilly AstraZeneca Johnson & Johnson Sunovion Pharmaceuticals Roscoe Medical Acura Pharmaceuticals Teva Pharmaceutical Cara Therapeutics Collegium Pharmaceutical Durect Corporation