Table of Contents Introduction Post-Operative Pain - Overview Post-Operative Pain - Therapeutics Development Post-Operative Pain - Therapeutics Assessment Post-Operative Pain - Companies Involved in Therapeutics Development Post-Operative Pain - Drug Profiles Post-Operative Pain - Dormant Projects Post-Operative Pain - Discontinued Products Post-Operative Pain - Product Development Milestones Appendix

List of Tables Number of Products under Development for Post-Operative Pain, H1 2019 Number of Products under Development by Companies, H1 2019 Number of Products under Development by Universities/Institutes, H1 2019 Products under Development by Companies, H1 2019 Products under Development by Universities/Institutes, H1 2019 Number of Products by Stage and Target, H1 2019 Number of Products by Stage and Mechanism of Action, H1 2019 Number of Products by Stage and Route of Administration, H1 2019 Number of Products by Stage and Molecule Type, H1 2019 Post-Operative Pain - Pipeline by Abide Therapeutics Inc, H1 2019 Post-Operative Pain - Pipeline by AcelRx Pharmaceuticals Inc, H1 2019 Post-Operative Pain - Pipeline by Adynxx Inc, H1 2019 Post-Operative Pain - Pipeline by AngioChem Inc, H1 2019 Post-Operative Pain - Pipeline by Aoxing Pharmaceutical Company Inc, H1 2019 Post-Operative Pain - Pipeline by Apsen Farmaceutica SA, H1 2019 Post-Operative Pain - Pipeline by Cadila Healthcare Ltd, H1 2019 Post-Operative Pain - Pipeline by Camurus AB, H1 2019 Post-Operative Pain - Pipeline by Cara Therapeutics Inc, H1 2019 Post-Operative Pain - Pipeline by Cellix Bio Pvt Ltd, H1 2019 Post-Operative Pain - Pipeline by CerSci Therapeutics Inc, H1 2019 Post-Operative Pain - Pipeline by Cytogel Pharma LLC, H1 2019 Post-Operative Pain - Pipeline by Dompe Farmaceutici SpA, H1 2019 Post-Operative Pain - Pipeline by DURECT Corp, H1 2019 Post-Operative Pain - Pipeline by Esteve Pharmaceuticals SA, H1 2019 Post-Operative Pain - Pipeline by Eupraxia Pharmaceuticals Inc, H1 2019 Post-Operative Pain - Pipeline by EyeGate Pharmaceuticals Inc, H1 2019 Post-Operative Pain - Pipeline by Fujimoto Pharmaceutical Corp, H1 2019 Post-Operative Pain - Pipeline by Grunenthal GmbH, H1 2019 Post-Operative Pain - Pipeline by Heron Therapeutics Inc, H1 2019 Post-Operative Pain - Pipeline by Immupharma Plc, H1 2019 Post-Operative Pain - Pipeline by Innocoll AG, H1 2019 Post-Operative Pain - Pipeline by Insys Therapeutics Inc, H1 2019 Post-Operative Pain - Pipeline by Ionis Pharmaceuticals Inc, H1 2019 Post-Operative Pain - Pipeline by iX Biopharma Ltd, H1 2019 Post-Operative Pain - Pipeline by Jiangsu Hengrui Medicine Co Ltd, H1 2019 Post-Operative Pain - Pipeline by Liquidia Technologies Inc, H1 2019 Post-Operative Pain - Pipeline by Lumosa Therapeutics Co Ltd, H1 2019 Post-Operative Pain - Pipeline by MedinCell SA, H1 2019 Post-Operative Pain - Pipeline by Medtronic Plc, H1 2019 Post-Operative Pain - Pipeline by Mundipharma International Ltd, H1 2019 Post-Operative Pain - Pipeline by Neumentum Inc, H1 2019 Post-Operative Pain - Pipeline by Novartis AG, H1 2019 Post-Operative Pain - Pipeline by Ocular Therapeutix Inc, H1 2019 Post-Operative Pain - Pipeline by Pacira Pharmaceuticals Inc, H1 2019 Post-Operative Pain - Pipeline by PainReform Ltd, H1 2019 Post-Operative Pain - Pipeline by Pharmaleads SA, H1 2019 Post-Operative Pain - Pipeline by PhytoHealth Corp, H1 2019 Post-Operative Pain - Pipeline by PixarBio Corp, H1 2019 Post-Operative Pain - Pipeline by PolyPid Ltd, H1 2019 Post-Operative Pain - Pipeline by RaQualia Pharma Inc, H1 2019 Post-Operative Pain - Pipeline by Recro Pharma Inc, H1 2019 Post-Operative Pain - Pipeline by Rottapharm Biotech Srl, H1 2019 Post-Operative Pain - Pipeline by Serina Therapeutics Inc, H1 2019 Post-Operative Pain - Pipeline by Shijiazhuang Yiling Pharmaceutical Co Ltd, H1 2019 Post-Operative Pain - Pipeline by Sichuan Kelun Pharmaceutical Co Ltd, H1 2019 Post-Operative Pain - Pipeline by SiteOne Therapeutics Inc, H1 2019 Post-Operative Pain - Pipeline by SteadyMed Therapeutics Inc, H1 2019 Post-Operative Pain - Pipeline by Taiwan Liposome Co Ltd, H1 2019 Post-Operative Pain - Pipeline by Teikoku Pharma USA Inc, H1 2019List of Figures Number of Products under Development for Post-Operative Pain, H1 2019 Number of Products under Development by Companies, H1 2019 Number of Products under Development by Universities/Institutes, H1 2019 Number of Products by Top 10 Targets, H1 2019 Number of Products by Stage and Top 10 Targets, H1 2019 Number of Products by Top 10 Mechanism of Actions, H1 2019 Number of Products by Stage and Top 10 Mechanism of Actions, H1 2019 Number of Products by Top 10 Routes of Administration, H1 2019 Number of Products by Stage and Top 10 Routes of Administration, H1 2019 Number of Products by Molecule Types, H1 2019 Number of Products by Stage and Molecule Types, H1 2019

Abide Therapeutics Inc AcelRx Pharmaceuticals Inc Adynxx Inc AngioChem Inc Aoxing Pharmaceutical Company Inc Apsen Farmaceutica SA Cadila Healthcare Ltd Camurus AB Cara Therapeutics Inc Cellix Bio Pvt Ltd CerSci Therapeutics Inc Cytogel Pharma LLC Dompe Farmaceutici SpA DURECT Corp Esteve Pharmaceuticals SA Eupraxia Pharmaceuticals Inc EyeGate Pharmaceuticals Inc Fujimoto Pharmaceutical Corp Grunenthal GmbH Heron Therapeutics Inc Immupharma Plc Innocoll AG Insys Therapeutics Inc Ionis Pharmaceuticals Inc iX Biopharma Ltd Jiangsu Hengrui Medicine Co Ltd Liquidia Technologies Inc Lumosa Therapeutics Co Ltd MedinCell SA Medtronic Plc Mundipharma International Ltd Neumentum Inc Novartis AG Ocular Therapeutix Inc Pacira Pharmaceuticals Inc PainReform Ltd Pharmaleads SA PhytoHealth Corp PixarBio Corp PolyPid Ltd RaQualia Pharma Inc Recro Pharma Inc Rottapharm Biotech Srl Serina Therapeutics Inc Shijiazhuang Yiling Pharmaceutical Co Ltd Sichuan Kelun Pharmaceutical Co Ltd SiteOne Therapeutics Inc SteadyMed Therapeutics Inc Taiwan Liposome Co Ltd Teikoku Pharma USA Inc Trevena Inc Xigen SA YiChang Humanwell Pharmaceutical Co Ltd